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Cell surface surprise: NPM1 is an immune therapy target for acute myeloid leukemia

Hansen J Kosasih1,2, Charles E de Bock1,2

  • 1Lowy Cancer Research Centre, Children's Cancer Institute UNSW Sydney Kensington New South Wales Australia.

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|August 11, 2025
PubMed
Abstract

No abstract available in PubMed .

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Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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