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Association Between Stone Composition and Recurrence Rates Following Ureteroscopy: A Scoping Review
Althea O George1, Mayowa Adefehinti2, Minwook Lee3
1Surgery/Urology, The Royal London Hospital, London, GBR.
Cureus
|August 11, 2025
Summary
Kidney stone composition impacts recurrence after ureteroscopy, with calcium oxalate stones showing higher rates. More research is needed due to inconsistent data and study limitations.
Area of Science:
- Urology
- Nephrology
- Biochemistry
Background:
- Urolithiasis (kidney stones) is a major health issue with frequent recurrence after treatment.
- Ureteroscopy is a common treatment, but stone recurrence remains a significant problem.
Purpose of the Study:
- To review the relationship between kidney stone composition and recurrence rates after ureteroscopy.
- To identify gaps in current research to guide future clinical practice and studies.
Main Methods:
- A scoping review of literature published between 2014 and 2024 from major databases.
- Included studies focused on adult ureteroscopy for kidney/ureteric stones with data on stone composition and recurrence.
- Excluded non-English studies, pediatric cases, and studies lacking essential data.
Main Results:
- Thirteen studies met the criteria; calcium oxalate stones were most common and linked to higher recurrence (up to 60% over 36 months).
- Recurrence rates were higher in patients without metabolic follow-up.
- Inconsistent reporting of uric acid, struvite, and cystine stones limited conclusions.
Conclusions:
- Stone composition, especially calcium-based stones, appears to influence post-ureteroscopy recurrence risk.
- Study limitations include retrospective designs, small sample sizes, varied recurrence definitions, and lack of metabolic data.
- Standardized prospective research with broader language inclusion is necessary to strengthen evidence.
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