Related Experiment Video
Updated: Sep 11, 2025
07:57
Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
12.6K
Hemoadsorption as Adjunctive Therapy in Streptococcal Toxic Shock Syndrome.
Gonçalo Miranda1,2,3, Vasco Neves1,2, Ricardo Tjeng1,2,3
1Intensive Care Unit, Unidade Local de Saúde Cova da Beira, Covilhã, PRT.
Cureus
|August 11, 2025
Summary
Group A Streptococcus (GAS) caused severe illness in a patient. Hemoadsorption therapy, alongside standard treatments, helped the patient recover, suggesting it may aid in treating streptococcal toxic shock syndrome (STSS).
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Nephrology
Background:
- Group A Streptococcus (GAS) is a significant pathogen causing severe invasive infections like necrotizing fasciitis and streptococcal toxic shock syndrome (STSS).
- STSS is characterized by high morbidity and mortality rates, often necessitating intensive care unit (ICU) admission for septic shock and multiorgan failure.
Observation:
- A case report details a 70-year-old male admitted to the ICU with septic shock and multiorgan failure secondary to GAS bacteremia.
- The patient received a combination of broad-spectrum antibiotics, intravenous immunoglobulin, and comprehensive organ support.
Findings:
- Organ support included vasopressors and renal replacement therapy.
- Hemoadsorption therapy utilizing the Jafron HA380 cartridge was administered as part of the treatment regimen.
- The patient demonstrated progressive clinical improvement and achieved a full recovery.
Implications:
- Hemoadsorption may play a crucial role in managing STSS by potentially reducing circulating inflammatory mediators.
- This case highlights the potential of hemoadsorption as an adjunctive therapeutic strategy for severe GAS infections and STSS.
- Further research into hemoadsorption's efficacy in critical care settings for infectious diseases is warranted.
Related Concept Videos
01:22Heart Failure VI: Adjunct Therapies
27
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
27
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
01:28Acute Coronary Syndrome IV: Interprofessional Care
27
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
27
01:14Prevention of Further Absorption of Poison
925
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
925
01:24Blood Pressure Imbalances and Circulatory Shock
1.0K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.0K
01:26EDTA: Auxiliary Complexing Reagents
672
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
672