Related Experiment Video

Updated: Sep 11, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K

Eight-Year Survival Analysis of Patients With Dilated Cardiomyopathy: Does Treatment Era Affect Prognosis?

Lukas Kucera1, Martin Chudý1, Marcela Danková1

  • 1Department of Heart Failure and Heart Transplantation, Faculty of Medicine, Comenius University, Bratislava, SVK.

Cureus
|August 11, 2025
PubMed

Insights

Dilated cardiomyopathy (DCM) survival remained stable despite recent patients having more severe disease. Older age, advanced kidney disease, and higher NT-proBNP levels predict worse outcomes in DCM patients.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Dilated cardiomyopathy (DCM) is a primary cause of heart failure (HF).
  • Understanding long-term survival and prognostic factors in DCM is crucial for patient management.

Purpose of the Study:

  • To retrospectively analyze long-term survival in patients with DCM.
  • To investigate the impact of various clinical factors on DCM prognosis over different time periods.

Main Methods:

  • Retrospective analysis of 622 DCM patients.
  • Comparison of survival rates between cohorts diagnosed in 2016-2019 and 2020-2023.
  • Multivariable analysis to identify independent predictors of survival.

Main Results:

  • Overall survival was comparable between the two periods (p=0.856), with the later period reflecting shorter follow-up.
  • Patients diagnosed between 2020-2023 exhibited a higher prevalence of NYHA class III/IV and larger ventricular diameters.
  • Independent negative predictors for survival included older age, NYHA class III/IV, CKD stages 3-5, diabetes, and elevated NT-proBNP (>3000 ng/L).
  • Female sex and overweight status were associated with improved survival.

Conclusions:

  • Survival rates for DCM patients have remained stable, even with a recent increase in patient severity.
  • Clinical factors like age, disease severity, comorbidities (CKD, diabetes), and NT-proBNP levels significantly influence DCM prognosis.
  • The findings suggest a need for continued monitoring and tailored management strategies for DCM patients, considering potential influences like the COVID-19 pandemic.

Keywords:
comorbiditiesdilated cardiomyopathyheart failureheart transplantationlong-term prognosis

More Related Videos

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.8K
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
22
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
33
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
48
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
455
Actuarial Approach01:20

Actuarial Approach

The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
135
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
40