Effective Management of Familial Erythrokeratoderma Using Topical Calcipotriol

Progressive symmetrical erythrokeratoderma (PSEK) is a rare genodermatosis that is inherited in an autosomal dominant pattern. It is clinically characterized by the insidious onset of well-defined, non-migratory, erythematous, hyperkeratotic plaques in a symmetrical distribution over the extremities. Hereby, we describe two cases of PSEK in a father and daughter, who presented with bilaterally symmetrical hyperpigmented scaly plaques, with skin biopsy findings suggestive of erythrokeratoderma. The skin lesions resolved with topical calcipotriol monotherapy, without the use of topical corticosteroids or oral medications. During telephonic follow-up, the patients reported that recurrences also responded well to topical calcipotriol, without the need for additional medication. This case report highlights the use of topical calcipotriol as a safe and effective therapeutic alternative for the treatment of erythrokeratoderma.