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Deprescribing in Patients with Intellectual Disability
Larrilyn Grant1, Kari Harper1, Julie P Gentile1
1All authors are with the Department of Psychiatry at Wright State University in Dayton, Ohio.
Innovations in Clinical Neuroscience
|August 11, 2025
Summary
Individuals with intellectual disability (ID) experience higher rates of mental illness and polypharmacy. Adapted psychotherapy and deprescribing protocols can improve quality of life for these patients.
Area of Science:
- Psychiatry
- Intellectual Disability Research
- Pharmacology
Background:
- Mental illness is more prevalent in individuals with intellectual disability (ID) compared to the general population.
- Individuals with ID often have limited coping mechanisms and support systems, increasing vulnerability to stress.
- Polypharmacy is common in patients with co-occurring ID and mental illness, often continuing after institutional discharge.
Purpose of the Study:
- To review the application of adapted psychotherapy for patients with intellectual disability.
- To discuss deprescribing protocols for managing polypharmacy in this population.
- To highlight strategies for improving the quality of life for individuals with ID and mental illness.
Main Methods:
- Review of adapted psychotherapy techniques suitable for individuals with ID.
- Examination of deprescribing protocols and their effectiveness in reducing polypharmacy.
- Analysis of case studies illustrating diagnostic and treatment approaches.
Main Results:
- Adapted psychotherapy can be effective for individuals with ID.
- Deprescribing protocols offer a structured approach to reducing unnecessary medications.
- Integrated mental and physical health management is crucial for this population.
Conclusions:
- Psychotherapy, adapted for intellectual disability, can enhance mental health outcomes.
- Systematic deprescribing is essential for managing polypharmacy and improving patient safety.
- Comprehensive care strategies are needed to improve the quality of life for individuals with ID and co-occurring mental illness.
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