Association of Mean Platelet Volume Expression with Bone Mineral Density in Patients with T2DM and CKD

To investigate the clinical significance of mean platelet volume (MPV) in patients with type 2 diabetes mellitus (T2DM) complicated with chronic kidney disease (CKD), and its association with bone mineral density (BMD).

A retrospective analysis was conducted on 296 T2DM patients with CKD. Based on MPV values, patients were divided into Group A (n=177, MPV 7.50-11.00 fL) and Group B (n=119, MPV >11.00 fL). Clinical and biochemical parameters including BMD were compared between groups. Pearson correlation and multiple linear regression were used to evaluate the relationship between MPV and BMD.

Group A showed significantly higher levels of PLT, SUA, and L1-L4 BMD than Group B (P<0.05); no statistically significant differences were found in other indicators between the groups (P>0.05). Pearson correlation analysis showed that MPV was negatively correlated with PLT (r=-0.253, P=0.012), SUA (r=-0.246, P=0.015), L1-L4 BMD (r=-0.351, P<0.01), femoral BMD (r=-0.271, P=0.007), and Ward BMD (r=-0.238, P=0.019). Multiple linear regression analysis revealed that high MPV was independently associated with lower L1-L4 BMD (β=-0.066, P=0.003).

High MPV is closely related to BMD in T2DM patients with CKD, especially L1-L4 BMD, and may serve as a potential indicator for the occurrence of osteoporosis.