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VisR Ultrasound With Non-Normal ARF-AoS Incidence Interrogates Both Shear and Young's Elastic Moduli in Transversely
Sabiq Muhtadi1, Caterina M Gallippi1
1Joint Department of Biomedical Engineering, The University of North Carolina (UNC) at Chapel Hill, Chapel Hill, NC 27599 USA North Carolina State University (NCSU), Raleigh, NC 27695 USA.
IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control
|August 11, 2025
Summary
This study introduces a new ultrasound method using Viscoelastic Response (VisR) to measure tissue elasticity. The technique analyzes changes in elasticity with varying ultrasound angles to characterize anisotropic tissues like muscle.
Area of Science:
- Biomedical Ultrasound
- Biophysics
- Tissue Mechanics
Background:
- Viscoelastic Response (VisR) ultrasound assesses shear elastic moduli in anisotropic materials.
- Current methods are limited to normal incidence of acoustic radiation force (ARF) to the axis of symmetry (AoS).
- Interrogating Young's elastic moduli in anisotropic tissues remains a challenge.
Purpose of the Study:
- To evaluate the potential of VisR ultrasound for interrogating Young's elastic moduli in anisotropic media.
- To investigate if varying ARF incidence angles can provide more comprehensive elasticity information.
- To establish a novel method for characterizing tissue biomechanics.
Main Methods:
- Utilized in silico experiments with varying ARF-AoS incidence angles.
- Monitored the percent change in VisR-derived relative elasticity (ΔRE) against ARF-AoS incidence angle.
- Validated findings ex vivo using chicken and bovine muscle tissues.
Main Results:
- Relative elasticity (RE) at normal incidence correlated with longitudinal shear modulus (μL) alone.
- The change in RE (ΔRE) showed a strong linear correlation (0.97-0.99) with the ratio of longitudinal shear-to-Young's moduli (μL/EL).
- The slope of ΔRE versus ARF-AoS incidence angle statistically distinguished materials with subtle differences in μL/EL ratios and differentiated muscle tissues.
Conclusions:
- The rate of change of ΔRE with ARF-AoS incidence angle may serve as a novel biomarker for anisotropic tissues.
- This method offers a semi-quantitative approach to characterizing tissue properties.
- Potential applications include characterizing kidney, skeletal muscle, and breast tissues.
Keywords:
Ultrasound elastographyYoung’s modulusacoustic radiation force impulse (ARFI)shear elastic modulustransversely isotropic (TI) materialsviscoelastic response (VisR) ultrasoundMore Related Videos
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