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Related Concept Videos

Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

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Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
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Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

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Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
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Preparation of Amides01:29

Preparation of Amides

3.2K
Amides are synthesized by treating carboxylic acids with amines in the presence of dehydrating agents like dicyclohexylcarbodiimide (DCC).
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
3.2K
β-Dicarbonyl Compounds via Crossed Claisen Condensations01:18

β-Dicarbonyl Compounds via Crossed Claisen Condensations

3.3K
Crossed Claisen condensations are base-promoted reactions between two different ester molecules producing β-dicarbonyl compounds.  The reaction involving esters, with both containing α hydrogen, results in a mixture of four different products that are difficult to isolate. This reduces the synthetic utility of the reaction.
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Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

4.5K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
4.5K
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

5.1K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
5.1K

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Updated: Sep 11, 2025

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
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Silver dithiocarbamates derived from amino acid esters.

Vreni Behling1, Jakob Heinrich1, Dolores Díaz2

  • 1Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Humboldtstr. 8, 07743 Jena, Germany. phil.koehler@uni-jena.de.

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|August 11, 2025
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Summary

New silver dithiocarbamate compounds derived from amino acid esters were synthesized and characterized. These complexes exhibit moderate DNA binding abilities, suggesting potential applications in medicinal chemistry.

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Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Biophysical Chemistry

Background:

  • Silver compounds are explored for their diverse applications.
  • Dithiocarbamate ligands offer versatile coordination possibilities.
  • Amino acid esters provide a scaffold for novel ligand design.

Purpose of the Study:

  • Synthesize and characterize novel silver dithiocarbamate complexes.
  • Investigate the solid-state and solution structures of these compounds.
  • Evaluate the DNA binding affinity of the synthesized silver complexes.

Main Methods:

  • Synthesis via salt metathesis reactions.
  • Characterization using X-ray crystallography, DOSY NMR, and DFT calculations.
  • Biological evaluation through ethidium bromide displacement and DNA melting curve assays.

Main Results:

  • Five silver dithiocarbamate ester compounds (Ag(L1)-Ag(L5)) were successfully synthesized.
  • X-ray crystallography revealed 1D-polymeric and ribbon-like structures for Ag(L1), Ag(L4), and Ag(L5).
  • Solution studies indicated the presence of smaller aggregates, supported by DFT calculations.
  • Initial biological assays demonstrated moderate DNA binding capabilities.

Conclusions:

  • Novel silver dithiocarbamate complexes with amino acid ester-derived ligands were prepared.
  • Structural diversity was observed in both solid-state and solution phases.
  • The compounds show potential for DNA interaction, warranting further investigation.