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Devices for non-fragmented removal of thrombus via mechanical grip: a patent review

Łucja Aleksandra Żurawska1, Frank Gijsen1,2, Paul Breedveld3

  • 1Department of Biomechanical Engineering, Delft University of Technology, Delft, Netherlands.

Expert Review of Medical Devices
|August 11, 2025
PubMed

Insights

This review classifies patents for mechanical thrombectomy devices that remove blood clots whole. Analyzing grip mechanisms offers insights into improving these life-saving procedures and inspiring new device development.

Area of Science:

  • Medical Devices
  • Biomedical Engineering
  • Interventional Neurology

Background:

  • Thromboembolic conditions are a significant cause of death and disability worldwide.
  • Mechanical thrombectomy is a preferred treatment, with complete clot removal on first pass reducing risks.
  • Current literature lacks a comprehensive classification of existing thrombectomy devices.

Purpose of the Study:

  • To provide a comprehensive overview and classification of patented devices for non-fragmented thrombus removal using grip mechanisms.
  • To analyze design trends and identify potential areas for innovation in mechanical thrombectomy devices.

Main Methods:

  • A systematic search of the Patentscope database was conducted for internationally granted patents.
  • Keywords and patent classification codes were used to identify relevant patents.
  • 141 patents were identified and categorized based on the location and type of grip mechanism described.

Main Results:

  • The review identified and categorized various grip mechanisms used in mechanical thrombectomy devices.
  • Analysis of patent designs revealed trends in device development for complete thrombus removal.
  • The classification provides a structured overview of the technological landscape.

Conclusions:

  • The patent literature reveals diverse approaches to non-fragmented thrombus removal via grip mechanisms.
  • Understanding these designs can inform the development of next-generation mechanical thrombectomy devices.
  • This review serves as a valuable resource for researchers and developers in the field.
Abstract

Keywords:
Patentischemic strokestent retrieverthrombectomythrombus

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