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[Lymph node metastasis in the prostatic anterior fat pad and prognosis after robot-assisted radical prostatectomy]

  • 0Nankai University School of Medicine, Tianjin 300071, China.
Zhonghua Nan Ke Xue = National Journal of Andrology +

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August 11, 2025

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August 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Prostatic anterior fat pad (PAFP) lymph node metastasis (LNM) was found in 1.1% of prostate cancer patients after robot-assisted radical prostatectomy (RARP). PAFP LNM indicates poor pathological features but similar recurrence-free survival compared to pelvic LNM.

Area Of Science

  • Urology
  • Oncology
  • Pathology

Context

  • Robot-assisted radical prostatectomy (RARP) is a standard treatment for prostate cancer (PCa).
  • The prostatic anterior fat pad (PAFP) is routinely removed during RARP.
  • The significance of LNM within the PAFP is not fully understood.

Purpose

  • To investigate the incidence and characteristics of lymph node metastasis (LNM) in the PAFP of PCa patients.
  • To analyze the clinicopathological features and prognosis associated with PAFP LNM.
  • To evaluate the clinical significance of PAFP examination during RARP.

Summary

  • Lymph nodes were detected in 7.7% of PAFP samples, with LNM found in 1.1% of all patients (11/1003).
  • PAFP LNM was significantly associated with higher postoperative pathological stage (≥T3) and Gleason score (≥8).
  • No significant difference in biochemical recurrence-free survival was observed between patients with PAFP LNM only and those with pelvic LNM only.

Impact

  • The PAFP serves as a potential site for LNM in PCa patients.
  • PAFP LNM is linked to adverse pathological features, suggesting its importance in risk stratification.
  • Routine PAFP removal and examination during RARP are clinically significant for comprehensive staging and management.

Keywords: