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Genomic DNA in Eukaryotes

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Related Experiment Video

Updated: Sep 11, 2025

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

Published on: March 29, 2019

The TIGER/Islander resource for genomic islands.

Steven L Yu¹, Hannah M McClain¹, Ellis L Torrance¹

¹Sandia National Laboratories, Livermore, California, USA.

Microbiology Resource Announcements

|August 11, 2025

Summary

This summary is machine-generated.

Genomic islands (GIs) are mobile DNA elements in bacteria and archaea. Researchers discovered 1.75 million GIs across nearly half a million prokaryotic genomes using novel software.

Keywords:

bioinformatics comparative genomics genomic island sequence database

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Area of Science:

Microbiology
Genomics
Bioinformatics

Background:

Genomic islands (GIs) are mobile genetic elements found in prokaryotes.
These elements often carry genes that influence bacterial traits such as virulence and metabolism.
Many GIs are prophages, which have potential applications in therapeutic strategies.

Purpose of the Study:

To identify and catalog genomic islands across a large dataset of prokaryotic genomes.
To create a comprehensive database of GIs for further research.

Main Methods:

Application of proprietary TIGER and Islander software tools.
Analysis of approximately 460,000 prokaryotic genome sequences.

Main Results:

Identification of a substantial database containing approximately 1.75 million genomic islands.
Comprehensive cataloging of GIs across a vast collection of prokaryotic genomes.

Conclusions:

The study successfully generated a large-scale database of genomic islands.
This resource provides a foundation for understanding the role of GIs in prokaryotic evolution and function.