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Author Correction: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial.

Nature medicine·2026
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Structure and temporal stability of adolescent psychotic experiences: findings from a German longitudinal cohort study.

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"It Felt Good to Be Able to Say That Out Loud"-Therapeutic Alliance and Processes in AVATAR Therapy for People Who Hear Distressing Voices: Peer-Led Qualitative Study.

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Relational Therapies for People Who Hear Voices: Operationalisation and Current Status of an Emergent Group of Psychological Therapies.

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Relational work with distressing voices mirroring experiences of discrimination and marginalisation: Three illustrative cases of an extended form of AVATAR therapy (AV-EXT).

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Related Experiment Video

Updated: Sep 11, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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[Digital interventions for psychoses: current opportunities and challenges].

Melina Luker1, Mar Rus-Calafell2,3

  • 1Forschungs- und Behandlungszentrum für psychische Gesundheit, Fakultät für Psychologie, Ruhr-Universität Bochum, Bochum, Deutschland.

Der Nervenarzt
|August 11, 2025
PubMed
Summary

Digital interventions show promise for psychosis treatment, improving symptoms compared to standard care. More large trials are needed to confirm effectiveness and integrate these digital tools into routine mental healthcare.

Keywords:
EfficacyMental health servicesOutcomesPsychotherapyTechnology

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Area of Science:

  • Psychiatry and Digital Health
  • Clinical Psychology
  • Neuroscience

Context:

  • Psychosis treatment traditionally relies on pharmacotherapy and psychotherapy.
  • Digital interventions (DI) offer novel, accessible adjuncts to conventional care.
  • Recent advancements include virtual reality, smartphone, and online platforms for psychosis management.

Purpose:

  • To review the usability and efficacy of recent digital interventions for psychosis.
  • To assess the potential of DI in improving treatment outcomes for individuals with psychosis.
  • To identify challenges and future directions for DI in psychosis care.

Summary:

  • Emerging evidence indicates digital interventions can reduce positive, cognitive, and affective symptoms in psychosis.
  • Comparisons suggest DI may be effective against treatment as usual and other active therapies.
  • However, robust evidence from large-scale controlled trials remains limited.

Impact:

  • DI have the potential to enhance treatment outcomes and complement existing therapies for psychosis.
  • Further research is crucial for refining DI strategies and ensuring long-term efficacy.
  • Successful integration requires addressing implementation challenges, funding, and policy development for routine care.