Related Experiment Video
Updated: May 6, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
A thousand ways to tailor your tractography-based connectome
Alessandra Griffa1,2, Francois Rheault3, Alessandro Daducci4
1Leenaards Memory Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Chem. de Mont-Paisible 16, 1011, Lausanne, Switzerland. alessandra.griffa@gmail.com.
Abstract:
Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parcellation resolution: coarse or fine atlas? Edge weighting: streamline count, length, or microstructural properties? These choices give rise to a daunting garden of forking paths. In this article, we revise fundamental decisions you must make when planning to build a tractography-based connectome and their impact on its network analysis.

