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Mapping the current research landscape of metformin in cancer based on bibliometric analysis

Yuan Wang1, Sike He1, Ziqi Li1

  • 1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Discover Oncology
|August 11, 2025
PubMed

Insights

Metformin shows potential anticancer effects, impacting genes like TP53 and pathways such as AMPK/mTOR. This research maps its relevance in breast and colorectal cancers, aiding future studies.

Area of Science:

  • Oncology
  • Pharmacology
  • Bioinformatics

Background:

  • Metformin is a primary treatment for type 2 diabetes.
  • Growing evidence suggests metformin possesses anticancer properties.
  • Existing research is fragmented, hindering a unified understanding of metformin's role in cancer.

Purpose of the Study:

  • To systematically map the research landscape of metformin and cancer.
  • To uncover molecular mechanisms and therapeutic relevance of metformin in diverse cancer types.
  • To provide an integrated perspective for future cancer research.

Main Methods:

  • Bibliometric analysis framework.
  • Bioinformatics analyses.
  • Systematic mapping of research literature.

Main Results:

  • Identified key gene targets: TP53, SIRT1, and HIF1A.
  • Highlighted significant signaling pathways: AMPK/mTOR and p53.
  • Revealed frequent associations with breast and colorectal cancers.

Conclusions:

  • Metformin's anticancer potential is supported by identified molecular targets and pathways.
  • The study provides a cohesive overview of metformin's role across various cancers.
  • Findings can guide future research into metformin-based cancer therapies.
Keywords:
Bibliometric analysisCancerCiteSpaceGene TargetsMetforminVOSviewer

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