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Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

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Idiopathic Bilateral Optic Nerve Sheath Calcification.

Paulo Roberto M Passarini¹, Renata Fernandes Cunha¹, Gustavo S Boasquevisque²

¹Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, and.

Ophthalmic Plastic and Reconstructive Surgery

|August 11, 2025

Summary

This study reports a rare case of bilateral optic nerve calcifications in a Graves disease patient. The calcifications were stable over seven years, with no impact on vision or neurological function.

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Area of Science:

Ophthalmology
Neurology
Endocrinology

Background:

Graves disease is an autoimmune disorder often associated with thyroid eye disease (orbitopathy).
Intracranial and optic nerve calcifications are uncommon findings, particularly in the context of Graves disease.

Purpose of the Study:

To describe a unique case of bilateral optic nerve and intracranial calcifications in a patient with a history of Graves disease.
To evaluate the stability and clinical significance of these calcifications over time.

Main Methods:

A case report detailing a 61-year-old female patient with Graves disease and mild orbitopathy.
Neuro-ophthalmological examination, assessment of renal function, and serum calcium, phosphorus, and parathyroid hormone levels.
Comparison of two orbital CT scans performed seven years apart.

Main Results:

The patient presented with bilateral optic nerve calcifications and multiple intracranial calcifications.
Neuro-ophthalmological evaluation revealed no functional or anatomical compromise of the optic nerves.
Calcifications remained stable on CT scans over a seven-year period, with normal metabolic parameters.

Conclusions:

Bilateral optic nerve and intracranial calcifications can occur in patients with Graves disease.
These calcifications may be asymptomatic and stable over time, without affecting optic nerve function.
Further research is needed to understand the etiology and implications of such calcifications in this patient population.