Correlation of cell cycle-related kinase and SII with FIGO stage, lymph node metastasis, and prognosis of serous ovarian cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Positive cell cycle related kinase (CCRK) expression and high systemic immune inflammation index (SII) are linked to poorer prognoses in serous ovarian cancer patients. These markers show potential for predicting patient outcomes in clinical settings.
Area Of Science
- Oncology
- Immunology
- Biochemistry
Background
- Ovarian cancer often presents at advanced stages with low survival rates.
- The systemic immune inflammation index (SII) reflects inflammation and immune status, valuable in cancer prognosis.
- Cell cycle related kinase (CCRK) promotes tumor growth and is implicated in various cancers.
Purpose Of The Study
- To investigate the expression of CCRK and SII levels in serous ovarian cancer.
- To explore the relationship between CCRK, SII, and clinicopathological features and prognosis.
- To analyze the potential mechanisms of CCRK and SII in ovarian cancer development.
Main Methods
- Immunohistochemistry was used to detect CCRK expression in 315 serous ovarian cancer and 158 benign ovarian cystadenoma tissues.
- SII levels were compared between benign and malignant groups and correlated with clinicopathological features.
- Survival analysis was performed based on CCRK expression and SII levels.
Main Results
- CCRK expression and SII levels were significantly higher in serous ovarian cancer tissues compared to benign tissues.
- CCRK expression correlated with FIGO stage and lymph node metastasis.
- Both elevated CCRK and SII were associated with significantly lower patient survival rates.
Conclusions
- Positive CCRK expression and elevated SII are associated with the development of serous ovarian cancer.
- CCRK and SII show potential as predictive biomarkers for serous ovarian cancer prognosis.
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