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Reprogramming of Myeloid Responses to Volumetric Muscle Loss via Engineered Protein Nanoparticles

Jesus A Castor-Macias1,2, Celeste Piotto1,2, Paige Rudy1,2

  • 1Dept. of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.

ACS Nano
|August 11, 2025
PubMed
Summary

Volumetric muscle loss (VML) injuries trigger inflammatory responses impacting recovery. Targeting immune cells with AICAR-loaded nanoparticles can reduce inflammation and improve muscle regeneration outcomes.

Keywords:
Trem2fibrosismuscle stem cellsphagocytosissingle-cell RNA-Seq

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