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Related Experiment Video

Updated: Sep 11, 2025

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
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Assessing changes in ultraviolet radiation-exposed mouse skin using optical coherence tomography.

Anna V Vejlsby1, Celina Pihl2, Rozarin Delal Kara3

  • 1Technical University of Denmark, Department of Health Technology, Kongens Lyngby, Denmark.

Plos One
|August 11, 2025
PubMed
Summary

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This summary is machine-generated.

Optical coherence tomography (OCT) non-invasively assesses skin damage from UV radiation. OCT effectively monitored photodamage and the efficacy of prevention treatments like NMN, showing promise for early skin cancer detection.

Area of Science:

  • Dermatology and Biomedical Optics
  • Non-invasive imaging techniques for skin cancer research

Background:

  • Skin cancer is a prevalent malignancy often caused by excessive ultraviolet radiation (UVR) exposure.
  • Early detection and prevention of UV-induced photodamage are crucial for mitigating long-term skin cancer risks.
  • Non-invasive methods are needed to assess photodamage and treatment efficacy.

Purpose of the Study:

  • To investigate the utility of optical coherence tomography (OCT) for assessing UV-induced photodamage over time.
  • To evaluate the efficacy of systemic prevention treatments, nicotinamide mononucleotide (NMN) and polypodium leucotomos (PL), using OCT.
  • To correlate OCT-derived metrics with histological findings for validation.

Main Methods:

  • 81 hairless mice were used, with 75 exposed to UVR three times weekly for 7 months to induce photodamage.

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  • Mice received either NMN or PL systemic treatments.
  • OCT imaging was performed monthly on multiple body sites. Skin thickness and attenuation coefficient were quantified using a custom algorithm.

    • Main Results:

    • Significant differences in skin thickness and attenuation coefficient were observed between UVR-exposed and control groups after 7 months.
    • OCT showed no significant difference in attenuation coefficient between UVR + PL and UVR groups, but a significant difference between UVR + NMN and UVR groups.
    • OCT-derived skin thickness measurements strongly correlated with histological findings.

    Conclusions:

    • Optical coherence tomography (OCT) is a valuable tool for non-invasively monitoring skin photodamage.
    • OCT can effectively assess the efficacy of photodamage prevention treatments.
    • The findings support OCT's potential role in early skin cancer detection and management strategies.