Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch
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Published on: August 7, 2017
Ruixuan Deng1, Chao Gu2, Jiqun Wang2
1State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China.
Abstract:
An undescribed cyclic nonapeptide (1) was isolated from the crude root extract of the medicinal plant Stellaria yunnanensis Franch. Comprehensive spectral analysis was performed utilizing high-resolution mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectroscopy, and experimental and calculated circular dichroism spectroscopy to elucidate the structure of the cyclic nonapeptide (1), which was identified as cyclo-(Tyr-Ala-Thr-Leu-Thr-Ala-Phe-Ala-Thr). Anti-renal fibrosis activity evaluation of compounds 1-3 showed that they have potential for anti-renal fibrosis by reducing the expression of fibrotic protein collagen I in NRK-49F cells induced by TGF-β1.
