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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
Published on: March 10, 2020
Mini Review: How circular RNAs participate in neuro-degeneration
Sima Biswas1, Angshuman Bagchi1
1Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, Nadia 741235 West Bengal, India; DBT-funded Bioinformatics Infrastructure Facility (BIF), University of Kalyani, Kalyani, Nadia 741235 West Bengal, India.
Abstract:
Circular RNAs have important implications in the onsets of various neurodegenerative diseases. Their broad functionalities involve miRNA sponging and binding to RBPs. Some circular RNAs have protein-coding potentials through specialized mechanisms. These products have varied functional implications in neurodegenerative diseases. However, the exact mechanisms of their involvement are not yet fully understood. This review gives an overview of the roles of the circular RNAs and their derived protein products in the onsets of neurodegenerative diseases.
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