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Antihyperlipidaemic activity by flavonoids from the aerial part of Rhinacanthus nasutus
Mu-Shui Xie1, Xian-Ling Yuan1, Min Huang1
1School of Yao Medical, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530002, China.
Abstract:
Rhinacanthus nasutus is known as traditional medicine for the treatment of fungal infections, viral hepatitis and skin diseases in the Zhuang nationality of Guangxi. In this study, eleven known flavonoids were isolated from the aerial part of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D NMR and ESI-MS. To our knowledge, this is the first instance of documenting the identification of compounds 1-11 from this plant. The isolated flavonoids were evaluated for their antihyperlipidemic. 1-[6-hydroxy-2-methoxy-2″,2″-dimethylpyrano-(5″,6″:3,4)]-2-(3',-4'-methylenedioxyphenyl)-1,2-ethanedione (3), derrubone dimethyl ether (4) robustin-methylether (5), 5,7-dimethoxy-6-(3- methyl-2-butenyl)- 3',4'-(methylenedioxy) -isoflavone (6), which exhibited certain lipid-lowering activity.
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