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Updated: Sep 11, 2025

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
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Precision targeting of PERK in ischemia/reperfusion: Unresolved temporal dynamics and lipid transport mechanisms

Yi Li1, Songlin Zhang1, Hui Wu2

  • 1Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, China; Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, China; Department of Thoracic and Cardiac Surgery, Yichang Central People's Hospital, Yichang 443003, Hubei Province, China.

International Journal of Cardiology
|August 11, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Mitochondrial-associated membraneMyocardial ischemia/reperfusion injuryPERK

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Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...
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