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Serum Endoglin and Endocan Levels in Rosacea and Their Association with Cardiovascular Risk Factors: A Case-Control
Melodi Çekiç1, Ayşın Köktürk2, Lülüfer Tamer3
1Department of Dermatology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey.
Dermatology Practical & Conceptual
|August 12, 2025
Summary
Serum levels of endocan and endoglin did not differ in rosacea patients versus controls. However, endoglin levels correlated with clinical features and may indicate cardiovascular risk in rosacea.
Area of Science:
- Dermatology
- Vascular Biology
- Biomarker Research
Background:
- Rosacea is a chronic inflammatory skin condition linked to vascular changes.
- Endocan and endoglin are biomarkers implicated in inflammation and angiogenesis.
- These biomarkers may influence rosacea development and associated cardiovascular conditions.
Purpose of the Study:
- To evaluate serum endocan and endoglin levels in rosacea patients.
- To determine the association of these biomarkers with rosacea severity and comorbidities.
Main Methods:
- A case-control study included 44 rosacea patients and 33 healthy controls.
- Serum samples were analyzed for endocan and endoglin concentrations.
Main Results:
- No significant difference in serum endocan or endoglin levels between rosacea patients and controls.
- Biomarker levels correlated with clinical features like symptom and disease severity.
- Endoglin levels showed an association with waist circumference and BMI, unlike endocan.
Conclusions:
- Endocan and endoglin may be involved in rosacea pathogenesis.
- Endoglin may serve as a potential indicator of increased cardiovascular risk in individuals with rosacea.
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