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Engineered Nanofluidics for Molecular Recognition and Physical Perception.

Congcong Zhu1,2, Yuge Wu3,4, Xin Li3,4

  • 1State Key Laboratory of Phytochemistry and Natural Medicines, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, P.R. China.

Angewandte Chemie (International Ed. in English)
|August 12, 2025
PubMed
Summary
This summary is machine-generated.

Nanofluidics offers ultra-sensitive molecular recognition and physical perception using solid-state nanochannels. This review covers nanofabrication, sensing, and future biomimetic applications for enhanced ionic sensing.

Keywords:
Bio‐inspiredInterfaceIon transportNanofluidicsSensors

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Area of Science:

  • Nanotechnology
  • Biomimetics
  • Analytical Chemistry

Background:

  • Nanofluidics provides ultra-sensitive detection beyond traditional methods.
  • Solid-state nanochannels/nanopores require advanced surface modification and nanofabrication.
  • Molecular recognition and physical perception are key applications.

Purpose of the Study:

  • To systematically review solid-state nanochannel/nanopore development.
  • To explore nanofabrication methods, sensing principles, and transport characteristics.
  • To discuss strategies for perceiving molecules and physical stimuli.

Main Methods:

  • Review of nanofluidic device fabrication techniques.
  • Analysis of sensing principles and ion transport properties.
  • Examination of surface modification strategies for molecular recognition.

Main Results:

  • Solid-state nanochannels enable precise molecular and physical sensing.
  • Interface chemistry and ion transport significantly impact sensing performance.
  • Integration of biomimetic designs shows promise for ionic sensing.

Conclusions:

  • Nanofluidics is a powerful tool for sensitive detection.
  • Future research should focus on biomimetic designs for advanced ionic sensing.
  • Understanding interface chemistry is crucial for optimizing nanofluidic sensors.