Association Between Malnutrition and Sepsis-Associated Delirium: A Retrospective Analysis of the MIMIC-IV Database
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View abstract on PubMed
Summary
This summary is machine-generated.Malnutrition significantly increases the risk of delirium in sepsis patients. Addressing nutritional status in the ICU is crucial for improving outcomes and potentially reducing healthcare costs.
Area Of Science
- Critical Care Medicine
- Nutritional Science
- Neurology
Background
- Sepsis-associated delirium (SAD) is a common neurological complication of sepsis.
- SAD increases mortality and leads to long-term neuropsychiatric issues like anxiety and cognitive impairment.
- The relationship between nutritional status and SAD in sepsis patients is not well understood.
Purpose Of The Study
- To investigate the association between malnutrition and the incidence of sepsis-associated delirium (SAD) in intensive care unit (ICU) patients.
Main Methods
- Retrospective analysis of adult sepsis patients admitted to the ICU.
- Logistic regression and propensity score matching were used to analyze the association between malnutrition and delirium.
- Sensitivity analyses, including E-value, were performed to confirm findings.
Main Results
- The study included 25,716 patients; 3,132 were malnourished.
- Malnourished patients had a twofold higher risk of delirium (26.56% vs. 12.90%).
- Malnutrition showed a significant positive correlation with delirium occurrence (OR = 2.07, 95% CI = 1.88-2.29), consistent across sensitivity analyses.
Conclusions
- Malnutrition is a significant risk factor for delirium in sepsis patients.
- Early assessment and nutritional intervention for malnourished sepsis patients in the ICU are recommended.
- Addressing malnutrition may reduce delirium incidence, improve patient outcomes, and lower healthcare costs.
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