Candida glabrata Acalculous Cholecystitis in an Immunocompetent Host

Acalculous cholecystitis (AC) is an inflammatory condition of the gallbladder without the presence of gallstones. Although far less common than calculus cholecystitis, AC is associated with a mortality rate 10 times higher than that of calculus cholecystitis. While normally due to bacterial pathogens, opportunistic ones such as the fungi Candida species (spp) can be rare causative agents of AC, typically observed in those with underlying malignancy or immunosuppression. In this study, we present an unusual case of an immunocompetent patient who was afflicted by fluconazole-resistant Candida glabrata AC. Our case highlights the complexity of this diagnosis and the challenges providers may encounter while treating the underlying infection.