Related Experiment Video
Updated: Sep 11, 2025

Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Ocular post-transplant lymphoproliferative disorder after keratoplasty
Linna Liu1, Xiangxi Chen1, Jianhua Wu1
1Aier Eye Hospital of Wuhan University, Wuhan, China.
Purpose:
Epstein-Barr virus associated post-transplantation lymphoproliferative disorders (PTLD) is a common condition after solid-organ or allogeneic hematopoietic stem-cell transplants. But ocular involvement after keratoplasty remains a rare finding, and can be easily misdiagnosed.
Observations:
We report a case of a 59-year-old man who presented with masquerade uveitis of right eye 4 months post penetrating keratoplasty and was ultimately diagnosed with ocular PTLD. The diagnosis relied on the presence of Epstein-Barr virus DNA in aqueous sample and iris specimens showed the presence of a B cell clone. The ocular condition was in complete remission after 15 intravitreal injections of methotrexate.
Conclusions And Importance:
Local immunosuppression after keratoplasty can lead to ocular PTLD. Detection of Epstein-Barr virus DNA in intraocular fluid and tissue or cytological biopsy could help confirm the diagnosis.
More Related Videos
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Kidney Transplant III: Nursing Management
Angle Closure Glaucoma: Treatment

