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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Sep 11, 2025

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Light-stimulated smart thermo-responsive constructs for enhanced wound healing: A streamlined command approach.

Bingcheng Yi1,2, Lei Yu3, Yating Yang4

  • 1Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China.

Asian Journal of Pharmaceutical Sciences
|August 12, 2025
PubMed
Summary

This study presents a novel NIR-light-activated bilayer system for wound healing. It promotes cell ingrowth and matrix remodeling while providing antibacterial protection, accelerating skin regeneration.

Keywords:
Antibacterial nanofibersCentralization of authorityNear-infrared lightThermo-responsive hydrogelWound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Photothermal Therapy

Background:

  • Severe cutaneous wounds require effective matrix remodeling and antimicrobial strategies for efficient healing.
  • Current treatments often lack integrated approaches for simultaneous matrix regeneration and infection control.

Purpose of the Study:

  • To engineer a near-infrared light (NIR)-stimulated, thermo-responsive bilayer system for enhanced severe cutaneous wound reconstruction.
  • To develop a system that promotes cell ingrowth, matrix remodeling, and provides antibacterial protection.

Main Methods:

  • Fabrication of a bilayer system comprising a bFGF-loaded thermo-responsive hydrogel (matrix layer) and an antibacterial nanofibrous mat (top layer).
  • Utilized polydopamine-Cu2+ coated short nanofibers for photothermal effect triggering controlled drug release and antibacterial activity.
  • Incorporated poly(L-lactide-co-caprolactone) nanofibers functionalized with lysine-doped polydopamine and poly-l-lysine for enhanced antibacterial properties.

Main Results:

  • NIR stimulation induced a rapid temperature increase, triggering hydrogel gel-sol transition and controlled release of basic fibroblast growth factor (bFGF).
  • The system demonstrated significant antibacterial efficacy against E. coli and S. aureus upon NIR activation.
  • In vivo studies showed prevention of S. aureus infection, regulated neovascularization, and facilitated collagen remodeling for improved skin regeneration.

Conclusions:

  • The developed NIR-responsive smart bilayer system offers a promising strategy for severe cutaneous wound healing.
  • The system effectively integrates photothermal-triggered drug delivery, cell-matrix remodeling, and antibacterial functions.
  • This approach holds potential for advancing regenerative medicine applications in wound care.