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Published on: February 10, 2023
Venous thromboembolism in pregnancy: recent advances
Matija Kozak1,2, Benilde Cosmi2,3,4, Grigoris Gerotziafas2,5,6,7
1University Medical Centre Ljubljana, Department for Vascular Diseases, Medical Faculty Ljubljana, Ljubljana, Slovenia
Pregnancy significantly increases the risk of venous thromboembolism (VTE), a major cause of maternal mortality. New diagnostic tools and tailored treatments are improving outcomes for pregnant individuals and those postpartum.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Cardiovascular Medicine
Background:
- Venous thromboembolism (VTE) risk is substantially elevated during pregnancy and the postpartum period.
- Pregnancy-associated VTE is a leading cause of maternal morbidity and mortality.
- Subtle clinical presentations necessitate advanced diagnostic approaches.
Purpose of the Study:
- To provide a comprehensive review of current knowledge on pregnancy-related VTE.
- To highlight evolving diagnostic strategies and management protocols.
- To address under-recognized aspects of VTE in pregnancy.
Main Methods:
- Review of emerging diagnostic algorithms, including D-dimer-guided approaches and pregnancy-adapted YEARS criteria.
- Analysis of current prevention and treatment strategies, emphasizing low-molecular-weight heparin.
- Exploration of ongoing research in individualized prophylaxis and risk stratification.
Main Results:
- Pregnancy-adapted diagnostic criteria improve accuracy and reduce unnecessary imaging.
- Low-molecular-weight heparin remains the standard for VTE prevention and treatment.
- Research is advancing personalized prophylaxis and postpartum management.
Conclusions:
- Evolving diagnostic and management strategies are crucial for addressing pregnancy-associated VTE.
- Further research into individualized prophylaxis and risk stratification is needed.
- Comprehensive understanding and management of VTE are vital throughout pregnancy and postpartum.
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