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Demographic and Clinical Characteristics of Pediatric Uveitis Cases from a Referral Center in Turkey
Meltem Guzin Altınel1, Betul Sözeri2, Ferhat Demir3
1Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Insights
This study analyzed 153 children with uveitis, finding juvenile idiopathic arthritis (JIA)-associated uveitis most common. Early, aggressive treatment significantly improved visual acuity in pediatric uveitis cases.
Area of Science:
- Ophthalmology
- Pediatric Rheumatology
- Immunology
Background:
- Uveitis in children presents unique diagnostic and management challenges.
- Understanding the spectrum of pediatric uveitis is crucial for effective treatment.
- Juvenile Idiopathic Arthritis (JIA) is a significant cause of pediatric uveitis.
Purpose of the Study:
- To offer insights into the clinical presentation and management of pediatric uveitis.
- To enhance the understanding of uveitis in children.
- To improve treatment strategies for pediatric uveitis.
Main Methods:
- Retrospective evaluation of medical records from a tertiary care hospital in Turkey.
- Inclusion of 153 children diagnosed with uveitis.
- Analysis of demographic data, uveitis type, diagnosis, ocular complications, treatments, and visual outcomes.
Main Results:
- The most frequent diagnosis was juvenile idiopathic arthritis (JIA)-associated uveitis (38.5%).
- Anterior uveitis was the most common type (57.5%).
- Significant improvement in Best Corrected Visual Acuity (BCVA) was observed across all anatomical localizations post-treatment (p < 0.05).
Conclusions:
- Collaboration with pediatric rheumatology may influence the prevalence of JIA-associated uveitis.
- Early and aggressive treatment strategies are vital for controlling ocular inflammation.
- Effective management leads to better long-term visual prognosis in pediatric uveitis.
Purpose:
To provide insights into the presentation and management of uveitis in children, enhancing understanding and improving treatment strategies.
Methods:
A retrospective evaluation of medical records was conducted to gather data on children diagnosed with uveitis in Uveitis Department of a tertiary care hospital in Turkey.
Results:
The study included 153 children with uveitis, of which 84 (54.9%) were female and 69 (45.1%) were male. The mean age was 10.17 ± 4.14 years (2-16 years). The mean follow-up period was 32.04 ± 17.47 months (12-72 months). Eighty-eight children (57.5%) had anterior uveitis, 32 (20.9%) had intermediate uveitis, 2 (1.3%) had posterior uveitis, and 31 (20.3%) had panuveitis. The most common diagnosis was juvenile idiopathic arthritis (JIA)-associated uveitis, which occurred in 59 children (38.5%). Out of 260 eyes assessed, 25.7% (67/260) had at least one ocular complication at presentation. Of the 145 children with noninfectious uveitis, methotrexate (MTX) was prescribed to 131 (90.3%), azathioprine (AZA) to 35 (24.1%), mycophenolate mofetil (MMF) to 6 (4.1%), cyclosporine (CSA) to 5 (3.4%), adalimumab (ADA) to 87 (60%), and infliximab (IFX) to 26 (17.9%). At the end of follow-up BCVA was found to be significantly improved in all anatomic localizations (p < 0.05).
Conclusion:
In our study, the collaboration between our clinic and the pediatric rheumatology referral center may have contributed to the higher number of JIA uveitis and different results. Early and aggressive treatment strategies are important in early and long-term control of ocular inflammation thus resulting in better visual prognosis in pediatric uveitis.
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