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Updated: Aug 10, 2026

Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
Inhibition of phencyclidine percutaneous absorption by parenterally administered hypertonic saline
Abstract:
Four hours after topical application of phencyclidine hydrochloride to hairless (hr-1/hr-1) mice, the mean hepatic concentration of phencyclidine (512.8 ng/g) was significantly lower for mice that had received intraperitoneal injections of sodium chloride, 1.75 mol/L (3500 mOsm/kg), than for control mice that had received equal volumes of water by the same route (2108.5 ng/g) (p less than 0.05). Hypertonic saline instilled intraperitoneally seemed to inhibit percutaneous absorption of phencyclidine hydrochloride. The effect may have been mediated by production of cutaneous dehydration.
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