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Updated: Sep 11, 2025

Single-Particle Cryo-EM Data Collection with Stage Tilt using Leginon
Published on: July 1, 2022
Scaling laws for the noise-equivalent angle and C-tilt, G-tilt anisoplanatism due to scintillation: errata
Abstract:
We correct two errors in [Appl. Opt.64, E11 (2025)APOPAI0003-693510.1364/AO.553861] that do not alter the overall conclusions of the paper. The first error involves an erroneous factor of 1/2 in the log-amplitude covariance used to compute the noise-equivalent angle (NEA) due to scintillation and the root-mean-squared error (RMSE) between the centroid tilt (C-tilt) and gradient tilt (G-tilt). The second error is a missing normalization factor in the log-amplitude covariance for a spherical wave [see Eq. (20)]. In addition, we clarify an underlying assumption in our C-tilt definition. This last point is not an error, but is important when comparing the analytic solutions with the wave-optics simulation results and the formulated scaling laws. Despite these corrections, the scaling laws presented in the original work remain valid and continue to provide a good estimate of the NEA due to scintillation and the C-tilt, G-tilt RMSE.
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