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Penile calciphylaxis.

Ornela D Piñero1, Patricia A Fernández Pardal1, Mauro Coringrato1

  • 1Unidad de Dermatología, Hospital de Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina.

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|August 12, 2025
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Summary

Calciphylaxis, a rare disease often seen in dialysis patients, can cause penile necrosis. Intravenous sodium thiosulfate showed promise in treating this severe condition in a recent case study.

Keywords:
calcific arteriolopathycalciphylaxischronic kidney diseasepenile ulcer

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Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Medicine

Background:

  • Calciphylaxis is a rare and often fatal condition characterized by vascular calcification and skin necrosis.
  • It is most commonly diagnosed in patients with end-stage renal disease (ESRD), often those on dialysis.
  • Penile necrosis is an exceptionally rare manifestation of calciphylaxis with a historically poor prognosis.

Observation:

  • A 45-year-old male with type 2 diabetes and chronic renal failure on dialysis presented with painful, necrotic ulcers on the glans.
  • The patient exhibited dysregulated calcium and phosphate metabolism.
  • Imaging studies confirmed the presence of calcium deposits consistent with calciphylaxis.

Findings:

  • The diagnosis of calciphylaxis was established in the context of penile necrosis.
  • Treatment with intravenous sodium thiosulfate was administered.
  • The patient demonstrated a favorable clinical response to sodium thiosulfate therapy.

Implications:

  • This case highlights the importance of considering calciphylaxis in patients with ESRD presenting with unusual necrotic lesions, even in the penile region.
  • Intravenous sodium thiosulfate may represent a viable therapeutic option for penile calciphylaxis, warranting further investigation.
  • Successful management of this rare condition can improve patient outcomes and quality of life.