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Locally aggressive differentiated thyroid carcinoma.

F Tovi, J Goldstein

Journal of Surgical Oncology

|June 1, 1985

Summary

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Local infiltration of well-differentiated thyroid cancer into neck tissues is rare. Surgical excision followed by radioactive iodine (131I) therapy and hormone replacement offers long-term survival for most patients.

Area of Science:

Oncology
Endocrinology
Surgical Pathology

Background:

Local infiltration of adjacent structures by well-differentiated thyroid carcinoma is uncommon.
This study reviews 21 cases managed over two decades.

Purpose of the Study:

To describe the clinical experience and outcomes of managing thyroid cancer with local infiltration.
To evaluate the effectiveness of surgical and radioiodine treatment strategies.

Main Methods:

Retrospective review of 21 patients with thyroid cancer infiltrating adjacent neck structures.
Treatment involved total thyroidectomy, excision of infiltrated tissues, radioactive iodine (131I) scanning and therapy, and thyroid hormone replacement.

Main Results:

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Papillary carcinoma was the most common type.

Two-thirds of patients survived between 1 to 19 years post-treatment.

Four patients died from disease progression (uncontrolled local disease and distant metastases).

Conclusions:

Aggressive surgical management combined with radioactive iodine therapy and hormone replacement is effective for thyroid cancer with local infiltration.
Long-term survival is achievable, though disease progression remains a risk.