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Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Patent highlights June - July 2024.

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Drug Repurposing Patent Applications January-March 2025.

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Novel drug repurposing patents reveal surprising anticancer effects of SSRI antidepressants and potential new uses for antidiabetic and antimalarial drugs. These findings highlight global innovation in drug discovery for various diseases.

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Area of Science:

  • Pharmaceutical Science
  • Drug Discovery
  • Medicinal Chemistry

Background:

  • Drug repurposing offers a cost-effective strategy to identify new therapeutic applications for existing drugs.
  • Patent applications provide insights into emerging trends and innovations in pharmaceutical research.
  • The Patent Cooperation Treaty (PCT) facilitates global dissemination of novel scientific findings.

Purpose of the Study:

  • To review and highlight significant drug repurposing patent applications published in Q1 2025.
  • To identify unexpected therapeutic potentials of known compounds.
  • To showcase the global landscape of drug repurposing research.

Main Methods:

  • Systematic review of fifteen selected drug repurposing patent applications from the PCT published in Q1 2025.
  • Analysis of patent claims for novel therapeutic indications of existing drugs.
  • Categorization of findings based on drug class and potential disease targets.

Main Results:

  • Selective serotonin reuptake inhibitor (SSRI) antidepressants (sertraline, indatraline) show potential anticancer effects.
  • Sitagliptin, a DPP-4 inhibitor, is proposed for glioblastoma treatment.
  • Artemisinin derivatives may induce cell differentiation in myelodysplastic syndrome.
  • Bucillamine is suggested for organophosphate poisoning treatment.

Conclusions:

  • Emerging patent applications demonstrate significant innovation in drug repurposing.
  • Existing drugs are being explored for novel applications across oncology, neurology, hematology, and toxicology.
  • Research in drug repurposing is a global effort, with contributions from diverse international jurisdictions.