Comorbid pathologies and their impact on progressive supranuclear palsy: current view
1Institute of Clinical Neurobiology, Alberichgasse 5/13, Vienna, 1150, Austria. kurt.jellinger@univie.ac.at.
Journal of Neural Transmission (Vienna, Austria : 1996)
|August 12, 2025
Summary
Progressive supranuclear palsy (PSP) often presents with other neurodegenerative or systemic diseases. Understanding these co-pathologies is crucial for improving patient care and clinical trial design.
Area of Science:
- Neuroscience
- Neuropathology
Background:
- Progressive supranuclear palsy (PSP) is a tauopathy characterized by specific clinical and morphological features.
- Isolated PSP neuropathology is rare, with approximately 70% of cases exhibiting co-neuropathologies.
Purpose of the Study:
- To discuss the frequency and clinical impact of co-pathologies in PSP patients.
- To provide insight into pathogenic backgrounds for improved treatment strategies.
Main Methods:
- Review of existing literature on PSP co-pathologies and comorbidities.
- Analysis of the clinical impact and pathogenic mechanisms of comorbid conditions.
Main Results:
- PSP frequently co-occurs with Alzheimer-type, Lewy body, and TDP-43 pathologies, among others.
- Common comorbidities include hypertension, cardiovascular diseases, and diabetes mellitus.
Conclusions:
- Co-pathologies and comorbidities significantly impact PSP progression and outcomes.
- Clinical trials for PSP must consider these factors in their design and patient selection for better therapeutic outcomes.
Keywords:
Alzheimer diseaseComorbiditiesConcomitant pathologiesNeurodegenerative disordersProgressive supranuclear palsyMore Related Videos
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