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Permethrin Stimulates Fat Accumulation via Regulating Gut Microbiota and Its Metabolites in Mice
Jie Lin1,2, Zexiu Qi2, Ge Wang2
1Department of Health, Nutrition and Food Sciences, Florida State University, Tallahassee, Florida 32306, United States.
Abstract:
Permethrin, a commonly used type I pyrethroid insecticide, has been shown to induce insulin resistance and adipogenesis, however the molecular mechanisms driving these effects remain unclear. This research demonstrated that permethrin disrupts the balance of gut microbiota, particularly altering Firmicutes and Bacteroidetes ratios, leading to increased adipogenesis and metabolic disorders. Antibiotic treatment significantly alleviated the effects of permethrin, highlighting the potential role of gut microbiota in obesity and insulin resistance. Fecal microbiota transplantation further confirmed the causal role of microbiota in fat accumulation. Additionally, microbial metabolites such as butyrate and indole were found to mitigate the fat accumulation induced by permethrin. Overall, our findings reveal that permethrin promotes obesity through the regulation of gut microbiota and their metabolites, providing important new insights into the health risks associated with permethrin exposure.
Insights
Permethrin exposure disrupts gut bacteria, causing obesity and insulin resistance. Restoring gut microbiota balance with treatments like antibiotics or fecal transplants can reverse these effects, revealing new health risks.
Area of Science:
- Environmental Science
- Microbiology
- Metabolic Science
Background:
- Permethrin, a pyrethroid insecticide, is linked to insulin resistance and adipogenesis.
- The precise molecular mechanisms behind permethrin's metabolic effects are not fully understood.
Purpose of the Study:
- To investigate the role of gut microbiota in permethrin-induced metabolic disorders.
- To elucidate the molecular pathways linking permethrin exposure to obesity and insulin resistance.
Main Methods:
- Analysis of gut microbiota composition (Firmicutes/Bacteroidetes ratio) in response to permethrin.
- Assessment of permethrin's effects following antibiotic treatment and fecal microbiota transplantation.
- Quantification of microbial metabolites (butyrate, indole) and their impact on adipogenesis.
Main Results:
- Permethrin significantly altered gut microbiota balance, increasing adipogenesis and metabolic dysfunction.
- Antibiotic treatment and fecal microbiota transplantation ameliorated permethrin-induced metabolic effects.
- Microbial metabolites, including butyrate and indole, were found to reduce permethrin-driven fat accumulation.
Conclusions:
- Permethrin promotes obesity and insulin resistance by dysregulating gut microbiota and altering metabolite profiles.
- Gut microbiota and their metabolites play a critical role in mediating the adverse metabolic effects of permethrin.
- These findings offer novel insights into the health risks of permethrin exposure and potential therapeutic strategies.
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