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In Vitro Fertilization

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Related Experiment Video

Updated: Sep 11, 2025

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

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Published on: October 18, 2024

Comparison of Intrauterine Insemination Success Rates Using Donor Sperm Between Heterosexual and Female Couples: A

Andreia Gomes¹, Cristina Nogueira-Silva¹, Pedro Brandão²

¹Escola de Medicina da Universidade do Minho, Braga, Portugal.

JBRA Assisted Reproduction

|August 12, 2025

Summary

Intrauterine insemination with donated sperm showed similar success rates for both heterosexual and female couples. This suggests seminal fluid may not be essential for reproductive outcomes in assisted reproduction.

Keywords:

female couples fertility heterosexual couples intrauterine insemination live birth rate medically assisted reproduction

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Last Updated: Sep 11, 2025

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OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Area of Science:

Reproductive Medicine
Infertility Treatment
Sperm Donation

Background:

Intrauterine insemination (IUI) is a common assisted reproductive technology.
Donated sperm is used when male factor infertility is present or for single women and female couples.
The role of seminal fluid in IUI success is debated, particularly for female couples.

Purpose of the Study:

To compare the success rates of intrauterine insemination with donated sperm.
To evaluate outcomes between heterosexual couples and female couples undergoing IUI.

Main Methods:

Retrospective cohort study of 519 women undergoing IUI with donated sperm.
Comparison between 193 women in heterosexual relationships and 326 women in female relationships.
Inclusion criteria: first reproductive treatment, age 18-38, no known female fertility disorders.

Main Results:

No significant differences in reproductive outcomes between heterosexual and female couples.
Pregnancy rates: 35.8% (heterosexual) vs. 29.1% (female couples).
Live birth rates: 29.5% (heterosexual) vs. 24.8% (female couples).

Conclusions:

Intrauterine insemination with donated sperm yields comparable outcomes for heterosexual and female couples.
Absence of seminal fluid exposure in female couples did not negatively impact success rates.
Further research is needed on seminal fluid's role and potential immune tolerance in assisted reproduction.