Emerging treatment modalities for gastric cancer with peritoneal metastases: A systematic review
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View abstract on PubMed
Summary
This summary is machine-generated.Emerging treatments like intraperitoneal (IP) chemotherapy and hyperthermic intraperitoneal chemotherapy (HIPEC) show promise for gastric cancer with peritoneal metastases. Further research is needed to confirm their role alongside current therapies.
Area Of Science
- Oncology
- Surgical Oncology
- Gastroenterology
Background
- Gastric cancer frequently presents with advanced peritoneal metastases, leading to high mortality.
- Current treatment options for this stage are limited, primarily relying on palliative systemic therapy.
Purpose Of The Study
- To systematically review emerging therapeutic strategies for gastric cancer with peritoneal metastases.
- To evaluate response, toxicity, and survival outcomes of these novel treatments.
Main Methods
- A comprehensive literature search was conducted in PubMed, EMBASE, and Cochrane databases until December 8, 2023.
- Included studies prospectively investigated cancer treatments in adult patients with peritoneally metastasized gastric cancer.
Main Results
- 25 articles from nine countries were analyzed, covering systemic therapy, intraperitoneal (IP) chemotherapy, hyperthermic intraperitoneal chemotherapy (HIPEC) with or without cytoreductive surgery (CRS), and pressurized intraperitoneal aerosol chemotherapy (PIPAC).
- IP chemotherapy and CRS-HIPEC demonstrated encouraging median overall survival (OS) ranging from 11.0-23.9 months in selected patients, particularly those with a Peritoneal Cancer Index ≥20.
- CRS-HIPEC followed by early postoperative intraperitoneal chemotherapy (EPIC) had high complication rates.
Conclusions
- Limited prospective trials exist for gastric cancer with peritoneal metastases.
- Intraperitoneal chemotherapy and CRS-HIPEC show potential in specific patient groups, especially in Asia, but require more randomized evidence.
- Further prospective studies are essential to define the role of these treatments alongside systemic and targeted therapies.
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