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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Analysis of Population Pharmacokinetic Data01:12

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Quantitative Aspects of Drug-Receptor Interaction01:30

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The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
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Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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Random Sampling Method01:09

Random Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest. Among the various sampling methods used by...
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Related Experiment Video

Updated: Sep 11, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
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Correction: Prediction of drug target interaction based on under sampling strategy and random forest algorithm.

Feng Chen, Zhigang Zhao, Zheng Ren

    Plos One
    |August 12, 2025
    PubMed
    Summary

    This study corrects a previously published article's DOI. The corrected DOI ensures accurate citation and retrieval of scientific research for the scientific community.

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    Area of Science:

    • Bibliometrics
    • Scholarly Communication

    Context:

    • Accurate citation is crucial for scientific integrity.
    • Proper referencing facilitates research reproducibility and discovery.

    Purpose:

    • To correct a typographical error in a published article's Digital Object Identifier (DOI).
    • To ensure the long-term accessibility and correct identification of scientific literature.

    Summary:

    • A correction has been issued for the DOI of a scientific publication.
    • The updated DOI is 10.1371/journal.pone.0318420.

    Impact:

    • Ensures researchers can accurately access and cite the intended study.
    • Maintains the integrity of scientific records and databases.
    • Facilitates seamless retrieval of research findings.