Related Experiment Video
Updated: May 5, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
A study of micro-dosing-transferring from methadone to buprenorphine in NHS Dumfries & Galloway
Samantha Nairn1, Sean Steele1, Eilish Bell1
1NHS D&G, NHS Specialist Drug and Alcohol Service, 12-28 Lochfield Road, Dumfries, DG2 9BH, United Kingdom.
Objectives:
To find a novel way to successfully transition patients from methadone to buprenorphine and in turn reduce the percentage of methadone prescribed within National Health Service Dumfries & Galloway (NHS D&G).
Methods:
Three micro-dosing schedules were developed. Outcomes measured: patient numbers, success rates, prior methadone dose, Opiate Substitution Therapy following micro-dosing. A patient feedback questionnaire was developed.
Key Findings:
177 patients micro-dosed between 06/09/21 and 28/05/24. Around 132 patients successfully transitioned from methadone to buprenorphine through micro-dosing (74.5%). Shift in prescribing: 60.5% buprenorphine/39.5% methadone.
Conclusion:
Micro-dosing is now a standardized approach to transitioning from methadone to buprenorphine in NHS Dumfries & Galloway.
More Related Videos
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
09:54Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
Published on: March 8, 2020
Related Concept Videos
Bioavailability Study Design: Healthy Subjects Versus Patients
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring: Drug Analysis Methods