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Parents' experiences of pediatric hematopoietic stem cell transplantation: A systematic review and meta-synthesis

Maryam Maleki1, Abbas Mardani1, Mojtaba Vaismoradi2

  • 1Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.

Journal of Pediatric Nursing
|August 12, 2025
PubMed

Insights

Parents of children undergoing hematopoietic stem cell transplantation (HSCT) face significant caregiver burden. Holistic, family-centered care is essential to support parents

Area of Science:

  • Pediatric Hematology
  • Oncology
  • Stem Cell Transplantation
  • Family Caregiving
  • Psychosocial Support

Background:

  • Hematopoietic stem cell transplantation (HSCT) is a critical treatment for pediatric malignancies and genetic disorders.
  • Parents experience substantial emotional, psychological, and practical burdens during their child's HSCT journey.
  • Understanding these parental experiences is vital for developing effective support systems.

Purpose of the Study:

  • To synthesize and analyze existing evidence on parents' experiences with pediatric HSCT.
  • To gain a comprehensive understanding of the challenges and needs of parents during their child's HSCT.
  • To inform the development of family-centered care models.

Main Methods:

  • Systematic review with a meta-synthesis approach.
  • Searched five major databases (PubMed, Scopus, CINAHL, Web of Science, Embase) without time restrictions.
  • Included qualitative studies and qualitative components of mixed-methods studies focusing on parental experiences.

Main Results:

  • Included 24 qualitative and 1 mixed-methods study.
  • Identified five key themes: caregiver burden, support systems, family dynamics, coping strategies, and positive outcomes.
  • Highlighted the multifaceted nature of parental experiences during pediatric HSCT.

Conclusions:

  • Parents undergoing pediatric HSCT face significant challenges but also experience growth opportunities.
  • Emphasizes the need for holistic, family-centered care to alleviate caregiver burden and enhance support.
  • Calls for healthcare providers and policymakers to implement supportive measures, including mental health services and financial aid.
Abstract

Keywords:
ChildHematopoietic stem cell transplantParentQualitative researchSystematic review

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