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Chromogranin B: A versatile neuroendocrine protein regulating physiological and metabolic functions
Chandramouli Mukherjee1, Palki Chauksey1, Aamna Jain1
1National Brain Research Center, Manesar, Haryana 122052, India.
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Chromogranin B (CHGB) is a key member of the granin family of acidic proteins, predominantly localized in the secretory granules of professional secretory cells, such as neurons and neuroendocrine cells. It plays a crucial role in the regulated secretory pathway, influencing hormone storage, processing, and release. CHGB's role extends from cellular processes to systemic physiology, encompassing vesicular trafficking, calcium homeostasis, and immune regulation. CHGB dysfunction is linked to pathological conditions such as neurodegenerative diseases, cardiovascular disorders, and metabolic disorders. This review examines the multifaceted functions of CHGB at both the cellular and organismal levels, highlighting its role in maintaining cellular homeostasis and its potential link to metabolic dysfunction and related pathophysiology.
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