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Related Experiment Video

Updated: Sep 11, 2025

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

Organoid-driven nanomedicine platform development.

Jian Wang¹, Fuxiao Wang², Yingying Jiang²

¹MedEng-X Institutes, Shanghai University, Shanghai, 200444, China; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine SHU Branch, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

|August 12, 2025

Summary

Organoid models combined with nanomedicine delivery systems improve drug discovery and personalized medicine. This integration offers more accurate and efficient evaluation of therapeutic efficacy for better patient outcomes.

Keywords:

Drug screening Nanomedicine Organoid Personalized medicine Targeted delivery Toxicological evaluation

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Area of Science:

Biotechnology
Nanomedicine
Regenerative Medicine

Background:

Organoids, 3D in vitro cell cultures, mimic human tissue architecture and function.
Nanomedicine delivery systems enhance drug stability, control release, and enable targeted delivery.
Traditional 2D cell cultures lack the physiological relevance of organoids for drug testing.

Purpose of the Study:

To review advancements in organoid-driven nanomedicine platforms.
To explore applications in drug screening, toxicological evaluation, and personalized medicine.
To address challenges and future directions in this interdisciplinary field.

Main Methods:

Integration of organoid models with nanomedicine delivery systems.
Utilizing 3D cell structures for in vitro disease modeling and drug screening.
Leveraging nanocarriers for enhanced drug efficacy and targeted delivery.

Main Results:

Organoid-nanomedicine platforms provide more accurate and physiologically relevant therapeutic efficacy evaluation.
This combination facilitates improved drug development and personalized therapeutic strategies.
Demonstrated potential for enhanced drug screening and toxicological assessments.

Conclusions:

The synergy between organoids and nanomedicine represents a significant leap in drug discovery.
This approach promises to accelerate the development of effective and individualized treatments.
Future research should focus on overcoming current challenges to fully realize the potential of these platforms.