Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.4K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

40
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
40
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

114
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
114

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of <i>Streptococcus pyogenes</i> isolates with reduced beta-lactam susceptibility in a cohort of children with pharyngitis.

Antimicrobial agents and chemotherapy·2026
Same author

Global trends in norovirus genotype distribution among medically attended children with acute gastroenteritis, 2020-2025.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2026
Same author

Using gloves wisely: rethinking glove use for health, safety, and environmental sustainability.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Characteristics Associated With Positive Bacterial Blood Cultures in Pediatrics.

Journal of the Pediatric Infectious Diseases Society·2026
Same author

I Zinc, Therefore I Am: Context is Key.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Executive Summary: State-of-the-Art Review: Infectious Diarrhea.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Related Experiment Video

Updated: Sep 11, 2025

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

528

Monomicrobial Rothia spp. Bloodstream Infections in Pediatric Patients and Literature Review.

Joshua D Green1, Preeti Jaggi2, Mark D Gonzalez3

  • 1Emory University School of Medicine, Atlanta, GA, United States.

Journal of the Pediatric Infectious Diseases Society
|August 12, 2025
PubMed
Summary

Rothia spp. bloodstream infections are common in cancer patients, often following broad-spectrum antibiotics. Susceptibility testing is recommended to identify antibiotic-driven breakthrough infections.

Keywords:
Rothia sppblood culturesbloodstream infectionsbroad-spectrum antibioticsfever

More Related Videos

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip
06:11

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Published on: March 29, 2024

1.9K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.1K

Related Experiment Videos

Last Updated: Sep 11, 2025

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

528
Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip
06:11

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Published on: March 29, 2024

1.9K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.1K

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Hematology

Background:

  • Rothia spp. are increasingly recognized as opportunistic pathogens.
  • Bloodstream infections (BSIs) in immunocompromised patients require careful management.

Purpose of the Study:

  • To analyze the characteristics of monomicrobial Rothia spp. BSIs.
  • To identify risk factors and clinical features associated with Rothia spp. BSIs.
  • To evaluate the need for routine susceptibility testing for Rothia spp.

Main Methods:

  • Retrospective review of 51 monomicrobial Rothia spp. blood cultures from 2015 to 2024.
  • Analysis of patient demographics, clinical data, and treatment outcomes.
  • Correlation of Rothia spp. BSIs with prior antibiotic use and patient conditions.

Main Results:

  • Rothia spp. BSIs predominantly occurred in cancer and hematopoietic cell transplantation patients (71%).
  • Most infections (97%) were classified as true BSIs, with 78% following broad-spectrum antibiotic use.
  • Prolonged fever (>4 days) was a frequent clinical manifestation.

Conclusions:

  • Rothia spp. represent a significant cause of BSIs in immunocompromised hosts.
  • Broad-spectrum antibiotic use is a notable risk factor for these infections.
  • Routine susceptibility testing for Rothia spp. is crucial for guiding effective antimicrobial therapy and managing breakthrough infections.