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Decoding OSCC prognosis: Insights into age-linked patterns and survival dynamics using AJCC 8th edition and CAP
Dr Sandhya Sundar1, Dr Suganya Paneerseelvam1, Dr Pratibha Ramani1
1Department of Oral Pathology and microbiology, Saveetha Dental College & Hospitals, Saveetha institute of medical and technical sciences, Chennai 600077, Tamilnadu, India.
Journal of Stomatology, Oral and Maxillofacial Surgery
|August 12, 2025
Summary
This study on oral squamous cell carcinoma (OSCC) found that while older patients often present with advanced disease, depth of invasion and lymph node status are stronger predictors of stage than age. Personalized risk-based management is crucial for OSCC.
Area of Science:
- Oncology
- Pathology
- Cancer Research
Background:
- Oral squamous cell carcinoma (OSCC) is a prevalent oral cancer with increasing incidence.
- Understanding clinicopathological characteristics and prognostic factors is vital for effective patient management.
Purpose of the Study:
- To explore clinicopathological features and disease-free survival (DFS) in OSCC patients.
- To investigate age-related prognostic differences in OSCC.
- To identify independent predictors of advanced disease stage in OSCC.
Main Methods:
- Retrospective analysis of OSCC cases diagnosed in 2022.
- Utilized College of American Pathologists (CAP) protocol and AJCC 8th edition staging.
- Compared clinicopathological parameters between patients ≤50 years and >50 years.
Main Results:
- Older patients (>50 years) more frequently presented with advanced stage III/IV disease and had higher rates of lymph node involvement and adjacent structure invasion.
- Younger patients exhibited a greater proportion of stage II cancers and a higher mean depth of invasion (DOI).
- Depth of invasion (DOI) and lymph node status were identified as independent predictors of advanced stage in multivariate analysis, while age lost statistical significance.
Conclusions:
- Depth of invasion and lymph node status are stronger independent predictors of advanced stage in oral squamous cell carcinoma than patient age.
- Despite age correlations with disease extent, personalized, risk-based management strategies are essential for OSCC.
- The findings support the need for focused assessment of DOI and nodal status in OSCC staging and treatment planning.
Keywords:
AJCC 8th editionAgeCAP protocolsDepth of invasionLymph node metastasisOral squamous cell carcinomaPrognosisSurvival analysisMore Related Videos
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