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Decoding JMJD proteins in cardiovascular and cerebrovascular diseases: From structure to function

Guangzhi Hao1, Yiyang Chen2, Yong Liang1

  • 1Department of Neurosurgery, The General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.

Ageing Research Reviews
|August 12, 2025
PubMed

Insights

Jumonji C domain-containing (JMJD) proteins are key epigenetic regulators influencing cardiovascular and cerebrovascular diseases. Understanding their roles offers potential for new therapeutic strategies targeting these widespread conditions.

Area of Science:

  • Biochemistry
  • Epigenetics
  • Molecular Biology

Background:

  • Cardiovascular and cerebrovascular diseases are leading global causes of mortality and disability.
  • Epigenetic modifications, influenced by environmental factors, play a crucial role in disease susceptibility.
  • The Jumonji C domain-containing (JMJD) protein family acts as critical histone demethylases in epigenetic regulation.

Purpose of the Study:

  • To review the structural characteristics of JMJD family members.
  • To highlight the roles of JMJD proteins in cardiovascular and cerebrovascular disorders.
  • To explore potential pharmacological strategies targeting JMJD proteins.

Main Methods:

  • Literature review of recent studies on JMJD proteins.
  • Analysis of structural features of JMJD family members.
  • Synthesis of findings on JMJD protein involvement in disease pathology.

Main Results:

  • JMJD proteins are identified as pivotal epigenetic regulators in cardiac hypertrophy, atherosclerosis, myocardial ischemia-reperfusion injury, and ischemic stroke.
  • These proteins are implicated in pathological processes including oxidative stress, macrophage polarization, mitochondrial autophagy, and apoptosis.
  • The review details the involvement of specific JMJD proteins in disease mechanisms.

Conclusions:

  • JMJD proteins are critical epigenetic modulators in cardiovascular and cerebrovascular diseases.
  • Elucidating JMJD protein functions provides insights into disease pathogenesis.
  • Targeting JMJD proteins may offer novel therapeutic avenues for treating these conditions.

Keywords:
AtherosclerosisCardiac hypertrophyIschemic strokeJMJDStructure

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