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Related Experiment Videos

The concentration maximum concept in intravenous cholangiography.

M Behan, H Mok, C D Bell

    The British Journal of Radiology
    |August 1, 1977
    PubMed
    Summary

    Bile diversion did not change ioglycamate excretion after bolus injection but reduced it during infusion. This suggests biliary excretion is limited by maximum concentration, not transport maximum, supporting infusion for cholangiography.

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    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Hepatology

    Background:

    • Biliary excretion of contrast agents is crucial for diagnostic imaging.
    • Understanding the mechanisms governing ioglycamate excretion is important for optimizing intravenous cholangiography.

    Purpose of the Study:

    • To investigate the effect of bile diversion on ioglycamate excretion in rhesus monkeys.
    • To determine whether biliary excretion is limited by transport maximum or maximum concentration.

    Main Methods:

    • Measuring ioglycamate excretion in bile following intravenous bolus injection and infusion.
    • Implementing 5% and 100% bile diversion to alter bile salt circulation.
    • Analyzing bile volume and ioglycamate concentration under different diversion conditions.

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    Main Results:

    • Bolus injection: 100% bile diversion reduced bile volume, increased ioglycamate concentration, but unchanged excretion.
    • Intravenous infusion: 100% bile diversion did not change ioglycamate concentration but reduced excretion.
    • Maximum concentration appeared constant, independent of bile salt output, suggesting concentration-dependent limitation.

    Conclusions:

    • Biliary excretion of ioglycamate is limited by maximum concentration, not a fixed transport maximum.
    • Interruption of enterohepatic circulation affects transport maximum.
    • Infusion technique achieves maximum concentration, supporting its use in intravenous cholangiography.