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Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

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Related Experiment Video

Updated: Sep 11, 2025

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

A new method for automated olfactory threshold testing.

Veikko Surakka¹, Marko Björkbacka¹, Jani Lylykangas¹

¹Research Group for Emotions, Sociality, and Computing, Faculty of Information Technology and Communication Sciences, Tampere University, Tampere, Finland.

Chemical Senses

|August 12, 2025

Summary

This summary is machine-generated.

A new Automated Olfactory Threshold Test (AutomOT) device offers reliable and valid self-administered olfactory testing. This user-friendly tool accurately assesses olfactory thresholds for clinical use.

Keywords:

Sniffin’ Sticks automated technology sense of smell test–retest reliability threshold usability

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Last Updated: Sep 11, 2025

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Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

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Area of Science:

Neuroscience
Sensory Science
Medical Devices

Background:

Olfactory testing is crucial for diagnosing smell disorders.
Current clinical methods can be time-consuming and require trained personnel.
There is a need for accessible, self-administered olfactory assessment tools.

Purpose of the Study:

To develop and validate a novel, fully self-administered olfactory testing device, the Automated Olfactory Threshold Test (AutomOT).
To assess the reliability, usability, and accuracy of the AutomOT device in comparison to a standard clinical test.

Main Methods:

Technical development and testing of the AutomOT prototype for odor intensity delivery.
Two user studies involving participants with normal, hyposmic, and anosmic olfactory function.
Comparison of AutomOT results with the established Sniffin' Sticks olfactory test.

Main Results:

The AutomOT device demonstrated repeatable odor intensity delivery over multiple days.
High test-retest reliability was observed in participants with normal olfaction (r = 0.44 to 0.78).
Significant correlation (r = 0.48) was found between AutomOT and Sniffin' Sticks, indicating validity.

Conclusions:

The AutomOT test is a reliable, valid, and usable tool for clinical assessment of olfactory thresholds.
The device showed good usability and low subjective workload in user studies.
AutomOT offers a promising solution for self-administered olfactory testing.